A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function

A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function

Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations impart a “leaky” character to the affected he...

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Bibliographic Details
Main Authors: Gaia Ziraldo, Damiano Buratto, Yuanyuan Kuang, Liang Xu, Andrea Carrer, Chiara Nardin, Francesco Chiani, Anna Maria Salvatore, Gaetano Paludetti, Richard A. Lerner, Guang Yang, Francesco Zonta, Fabio Mammano
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Physiology
Subjects:
connexin hemichannels
rare diseases
phage display libraries
therapeutic monoclonal antibodies
molecular dynamics
patch clamp
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00392/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00392/full

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