The Effect of JAK1/2 Inhibitors on HIV Reservoir Using Primary Lymphoid Cell Model of HIV Latency

The Effect of JAK1/2 Inhibitors on HIV Reservoir Using Primary Lymphoid Cell Model of HIV Latency

HIV eradication is hindered by the existence of latent HIV reservoirs in CD4+ T cells. Therapeutic strategies targeting latent cells are required to achieve a functional cure, however the study of latently infected cells from HIV infected persons is extremely challenging due to the lack of biomarker...

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Bibliographic Details
Main Authors: Lesley R. de Armas, Christina Gavegnano, Suresh Pallikkuth, Stefano Rinaldi, Li Pan, Emilie Battivelli, Eric Verdin, Ramzi T. Younis, Rajendra Pahwa, Siôn L. Williams, Raymond F. Schinazi, Savita Pahwa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
HIV
latency
tonsil
scRNAseq
JAK-STAT signaling pathway
LRA (latency reversing agent)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.720697/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.720697/full

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