Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.

Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.

The CpG island methylator phenotype (CIMP) is a distinct phenotype associated with microsatellite instability (MSI) and BRAF mutation in colon cancer. Recent investigations have selected 5 promoters (CACNA1G, IGF2, NEUROG1, RUNX3 and SOCS1) as surrogate markers for CIMP-high. However, no study has c...

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Bibliographic Details
Main Authors: Katsuhiko Nosho, Natsumi Irahara, Kaori Shima, Shoko Kure, Gregory J Kirkner, Eva S Schernhammer, Aditi Hazra, David J Hunter, John Quackenbush, Donna Spiegelman, Edward L Giovannucci, Charles S Fuchs, Shuji Ogino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2579485?pdf=render

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http://europepmc.org/articles/PMC2579485?pdf=render

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