Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike

Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike

Broadly neutralizing antibodies (bNAbs) to HIV-1 envelope glycoprotein (Env) can prevent infection in animal models. Characterized bNAb targets, although key to vaccine and therapeutic strategies, are currently limited. We defined a new site of vulnerability by solving structures of bNAb 8ANC195 com...

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Bibliographic Details
Main Authors: Louise Scharf, Johannes F. Scheid, Jeong Hyun Lee, Anthony P. West Jr., Courtney Chen, Han Gao, Priyanthi N.P. Gnanapragasam, René Mares, Michael S. Seaman, Andrew B. Ward, Michel C. Nussenzweig, Pamela J. Bjorkman
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714002848

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http://www.sciencedirect.com/science/article/pii/S2211124714002848

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