Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis

Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis

Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins has been suggested in oligodendrocytes in ALS but the extent to which this affects myelination and t...

Full description

Bibliographic Details
Main Authors: Samantha K. Barton, Jenna M. Gregory, Bhuvaneish T. Selvaraj, Karina McDade, Christopher M. Henstridge, Tara L. Spires-Jones, Owen G. James, Arpan R. Mehta, David Story, Karen Burr, Dario Magnani, Adrian M. Isaacs, Colin Smith, Siddharthan Chandran
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neuroscience
Subjects:
oligodendrocytes
RNA trafficking
myelination
ALS
myelin basic protein
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.705306/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.705306/full

Similar Items