Transient Disappearance of RAS Mutant Clones in Plasma: A Counterintuitive Clinical Use of EGFR Inhibitors in RAS Mutant Metastatic Colorectal Cancer

Transient Disappearance of RAS Mutant Clones in Plasma: A Counterintuitive Clinical Use of EGFR Inhibitors in RAS Mutant Metastatic Colorectal Cancer

Genomic studies performed through liquid biopsies widely elucidated the evolutionary trajectory of RAS mutant clones under the selective pressure of EGFR inhibitors in patients with wild type RAS primary colorectal tumors. Similarly, the disappearance of RAS mutant clones in plasma has been more rec...

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Bibliographic Details
Main Authors: Cristina Raimondi, Chiara Nicolazzo, Francesca Belardinilli, Flavia Loreni, Angela Gradilone, Yasaman Mahdavian, Alain Gelibter, Giuseppe Giannini, Enrico Cortesi, Paola Gazzaniga
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
metastatic colorectal cancer
circulating tumor DNA
RAS
EGFR inhibitors
Online Access:http://www.mdpi.com/2072-6694/11/1/42

Internet

http://www.mdpi.com/2072-6694/11/1/42

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