Evolution and Medical Significance of LU Domain−Containing Proteins

Evolution and Medical Significance of LU Domain−Containing Proteins

Proteins containing Ly6/uPAR (LU) domains exhibit very diverse biological functions and have broad taxonomic distributions in eukaryotes. In general, they adopt a characteristic three-fingered folding topology with three long loops projecting from a disulfide-rich globular core. The majority of the...

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Bibliographic Details
Main Authors: Julie Maja Leth, Katrine Zinck Leth-Espensen, Kristian Kølby Kristensen, Anni Kumari, Anne-Marie Lund Winther, Stephen G. Young, Michael Ploug
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
uPAR
snake venom α-neurotoxins
GPIHBP1
plesiotypic disulfide bonds
protein evolution
Ly6/uPAR domains
protein module
protein domain
Online Access:https://www.mdpi.com/1422-0067/20/11/2760

Internet

https://www.mdpi.com/1422-0067/20/11/2760

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