Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells

Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells

B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs). B7-H3-CARs containing a 41BB costimulatory domain are currently favored by several groups based on preclinical stu...

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Bibliographic Details
Main Authors: Phuong Nguyen, Emmanuel Okeke, Michael Clay, Dalia Haydar, Julie Justice, Carla O’Reilly, Shondra Pruett-Miller, James Papizan, Jennifer Moore, Sheng Zhou, Robert Throm, Giedre Krenciute, Stephen Gottschalk, Christopher DeRenzo
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
Chimeric antigen receptor
CAR
T cell
solid tumor
pediatric
B7-H3
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300978

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http://www.sciencedirect.com/science/article/pii/S2372770520300978

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