Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives

Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives

A small library of coumarin and their psoralen analogues EMAC10157a-b-d-g and EMAC10160a-b-d-g has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards carbonic anhydrase isoforms I, II, IX, and XII. None of t...

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Bibliographic Details
Main Authors: Rita Meleddu, Serenella Deplano, Elias Maccioni, Francesco Ortuso, Filippo Cottiglia, Daniela Secci, Alessia Onali, Erica Sanna, Andrea Angeli, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Simona Distinto
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
hcai
tumour
coumarin
psoralen
docking
Online Access:http://dx.doi.org/10.1080/14756366.2021.1887171

Internet

http://dx.doi.org/10.1080/14756366.2021.1887171

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