Insight into the structure of amyloid fibrils from the analysis of globular proteins.

The conversion from soluble states into cross-beta fibrillar aggregates is a property shared by many different proteins and peptides and was hence conjectured to be a generic feature of polypeptide chains. Increasing evidence is now accumulating that such fibrillar assemblies are generally character...

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Bibliographic Details
Main Authors: Antonio Trovato, Fabrizio Chiti, Amos Maritan, Flavio Seno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-12-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC1698942?pdf=render