Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease

Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease

Single nucleotide polymorphisms in PICALM, a key component of clathrin-mediated endocytosis machinery, have been identified as genetic susceptibility loci for late onset Alzheimer's disease (LOAD). We previously reported that PICALM protein levels were decreased in AD brains and that PICALM was...

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Bibliographic Details
Main Authors: Kunie Ando, Karen Tomimura, Véronique Sazdovitch, Valérie Suain, Zehra Yilmaz, Michèle Authelet, Marième Ndjim, Cristina Vergara, Mounir Belkouch, Marie-Claude Potier, Charles Duyckaerts, Jean-Pierre Brion
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Neurobiology of Disease
Subjects:
PICALM
Tau
NFTs
Alzheimer's disease
Pick disease
Progressive supranuclear palsy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301218

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http://www.sciencedirect.com/science/article/pii/S0969996116301218

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