An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients

An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients

Background and Aims: Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants further study. Inhibition of retinoic acid-related orphan receptor gamma (RORγt), the master regulator of the Th17 signature, is curren...

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Main Authors: Helena Bassolas-Molina, Ernest Raymond, Mark Labadia, Joseph Wahle, Elena Ferrer-Picón, Mark Panzenbeck, Jie Zheng, Christian Harcken, Robert Hughes, Michael Turner, Dustin Smith, Elisabeth Calderón-Gómez, Míriam Esteller, Anna Carrasco, Maria Esteve, Isabella Dotti, Ana Maria Corraliza, Maria Carme Masamunt, Clàudia Arajol, Jordi Guardiola, Elena Ricart, Gerald Nabozny, Azucena Salas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
Th17
commensal antigens
T-cell-transfer
RORγt inhibition
Crohn's disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02307/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02307/full

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