Maternal genetics influences fetal neurodevelopment and postnatal autism spectrum disorder-like phenotype by modulating in-utero immunosuppression

Abstract Genetic studies in ASD have mostly focused on the proband, with no clear understanding of parental genetic contributions to fetal neurodevelopment. Among parental etiological factors, perinatal maternal inflammation secondary to autoimmunity, infections, and toxins is associated with ASD. H...

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Bibliographic Details
Main Authors: Ritika Jaini, Matthew R. Wolf, Qi Yu, Alexander T. King, Thomas W. Frazier, Charis Eng
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01472-x