Structure, dynamics and immunogenicity of a catalytically inactive CXC chemokine-degrading protease SpyCEP from Streptococcus pyogenes

Structure, dynamics and immunogenicity of a catalytically inactive CXC chemokine-degrading protease SpyCEP from Streptococcus pyogenes

Over 18 million disease cases and half a million deaths worldwide are estimated to be caused annually by Group A Streptococcus. A vaccine to prevent GAS disease is urgently needed. SpyCEP (Streptococcus pyogenes Cell-Envelope Proteinase) is a surface-exposed serine protease that inactivates chemokin...

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Bibliographic Details
Main Authors: Sophie McKenna, Enrico Malito, Sarah L. Rouse, Francesca Abate, Giuliano Bensi, Emiliano Chiarot, Francesca Micoli, Francesca Mancini, Danilo Gomes Moriel, Guido Grandi, Danuta Mossakowska, Max Pearson, Yingqi Xu, James Pease, Shiranee Sriskandan, Immaculada Margarit, Matthew J. Bottomley, Stephen Matthews
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020300076

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http://www.sciencedirect.com/science/article/pii/S2001037020300076

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