Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling

Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling

Abstract Background Rewiring of metabolism induced by oncogenic K-Ras in cancer cells involves both glucose and glutamine utilization sustaining enhanced, unrestricted growth. The development of effective anti-cancer treatments targeting metabolism may be facilitated by the identification and ration...

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Main Authors: Daniela Gaglio, Marcella Bonanomi, Silvia Valtorta, Rohit Bharat, Marilena Ripamonti, Federica Conte, Giulia Fiscon, Nicole Righi, Elisabetta Napodano, Federico Papa, Isabella Raccagni, Seth J. Parker, Ingrid Cifola, Tania Camboni, Paola Paci, Anna Maria Colangelo, Marco Vanoni, Christian M. Metallo, Rosa Maria Moresco, Lilia Alberghina
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cancer & Metabolism
Subjects:
Metabolic rewiring
Metabolic cancer therapy
Metabolic signature
Glycolysis
Glutamine
Combinatorial drug treatment
Online Access:http://link.springer.com/article/10.1186/s40170-020-00227-4

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http://link.springer.com/article/10.1186/s40170-020-00227-4

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