A New Risk Variant for Multiple Sclerosis at 11q23.3 <i>Locus</i> Is Associated with Expansion of <i>CXCR5+</i> Circulating Regulatory T Cells

A New Risk Variant for Multiple Sclerosis at 11q23.3 <i>Locus</i> Is Associated with Expansion of <i>CXCR5+</i> Circulating Regulatory T Cells

Genome-wide association studies and meta-analysis have contributed to the identification of more than 200<i> loci</i> associated with multiple sclerosis (MS). However, a proportion of MS heritability remains unknown. We aimed to uncover new genetic variants associated with MS and determi...

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Bibliographic Details
Main Authors: Elia Gil-Varea, Maria Fedetz, Herena Eixarch, Nino Spataro, Luisa María Villar, Elena Urcelay, Albert Saiz, Óscar Fernández, Laura Leyva, Lluís Ramió-Torrentà, Koen Vandenbroeck, David Otaegui, Tamara Castillo-Triviño, Guillermo Izquierdo, Sunny Malhotra, Elena Bosch, Arcadi Navarro, Antonio Alcina, Xavier Montalban, Fuencisla Matesanz, Manuel Comabella
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Journal of Clinical Medicine
Subjects:
multiple sclerosis
genetics
targeted dna sequencing
genotyping
single nucleotide polymorphisms
<i>cxcr5</i>
Online Access:https://www.mdpi.com/2077-0383/9/3/625

Internet

https://www.mdpi.com/2077-0383/9/3/625

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