Alternative computational protocols for supercharging protein surfaces for reversible unfolding and retention of stability.

Alternative computational protocols for supercharging protein surfaces for reversible unfolding and retention of stability.

Reengineering protein surfaces to exhibit high net charge, referred to as "supercharging", can improve reversibility of unfolding by preventing aggregation of partially unfolded states. Incorporation of charged side chains should be optimized while considering structural and energetic cons...

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Bibliographic Details
Main Authors: Bryan S Der, Christien Kluwe, Aleksandr E Miklos, Ron Jacak, Sergey Lyskov, Jeffrey J Gray, George Georgiou, Andrew D Ellington, Brian Kuhlman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3669367?pdf=render

Internet

http://europepmc.org/articles/PMC3669367?pdf=render

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