LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

Background: Chronic inflammation and residual HIV transcription persist in people living with HIV (PLWH) receiving antiretroviral therapy (ART), thus increasing the risk of developing non-AIDS co-morbidities. The mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism and HI...

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Bibliographic Details
Main Authors: Delphine Planas, Amélie Pagliuzza, Rosalie Ponte, Augustine Fert, Laurence Raymond Marchand, Marta Massanella, Annie Gosselin, Vikram Mehraj, Franck P Dupuy, Stéphane Isnard, Jean-Philippe Goulet, Sylvie Lesage, Eric A. Cohen, Mager Peter Ghali, Jonathan B. Angel, Nicolas Chomont, Jean-Pierre Routy, Petronela Ancuta
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:EBioMedicine
Subjects:
Metformin
ART
HIV reservoirs
Th17
mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000633

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http://www.sciencedirect.com/science/article/pii/S2352396421000633

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