LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

Clustering of receptors associated with immunoreceptor tyrosine-based activation motifs (ITAMs) initiates the macrophage antimicrobial response. ITAM receptors engage Src-family tyrosine kinases (SFKs) to initiate phagocytosis and macrophage activation. Macrophages also encounter nonpathogenic molec...

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Bibliographic Details
Main Authors: Tanya S Freedman, Ying X Tan, Katarzyna M Skrzypczynska, Boryana N Manz, Frances V Sjaastad, Helen S Goodridge, Clifford A Lowell, Arthur Weiss
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
macrophage
cell signaling
Src-family kinases
innate immunity
ITAMs
receptor
Online Access:https://elifesciences.org/articles/09183

Internet

https://elifesciences.org/articles/09183

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