The balance between mitotic death and mitotic slippage in acute leukemia: a new therapeutic window?

Abstract Mitosis is the process whereby an eukaryotic cell divides into two identical copies. Different multiprotein complexes are involved in the fine regulation of cell division, including the mitotic promoting factor and the anaphase promoting complex. Prolonged mitosis can result in cellular div...

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Bibliographic Details
Main Authors: Andrea Ghelli Luserna di Rorà, Giovanni Martinelli, Giorgia Simonetti
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Hematology & Oncology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13045-019-0808-4