Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells
MALT1 regulates NFκB signalling both as a scaffolding protein and as a protease. Here the authors show that during T cell activation the expression of MALT1 gene switches to an alternatively spliced variant, which increases TCR signal transduction due to enhanced TRAF6 binding.
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-04-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms11292 |