Population Pharmacokinetic Modelling and Simulation to Determine the Optimal Dose of Nanoparticulated Sorafenib to the Reference Sorafenib

Population Pharmacokinetic Modelling and Simulation to Determine the Optimal Dose of Nanoparticulated Sorafenib to the Reference Sorafenib

Sorafenib, an oral multikinase inhibitor, exhibits a highly variable absorption profile due to enterohepatic reabsorption and poor solubility. SYO-1644 improved the solubility of sorafenib by nanoparticulation technology leading to enhanced bioavailability. To evaluate the pharmacokinetically equiva...

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Bibliographic Details
Main Authors: Ki Young Huh, Sejung Hwang, Sang Yeob Park, Hye Jung Lim, Miryung Jin, Jaeseong Oh, Kyung-Sang Yu, Jae-Yong Chung
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
sorafenib
pharmacokinetics
bioavailability
pharmacometrics
enterohepatic reabsorption
Online Access:https://www.mdpi.com/1999-4923/13/5/629

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https://www.mdpi.com/1999-4923/13/5/629

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