Endosomal Rab cycles regulate Parkin-mediated mitophagy
Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson’s disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autoph...
Main Authors: | , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-01-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/31326 |