Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice

Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice

PPARα (PPARA), expressed in most oxidative tissues, is a major regulator of lipid homeostasis; hepatic PPARA plays a critical role during the adaptive fasting response by promoting FA oxidation (FAO). To clarify whether extrahepatic PPARA activity can protect against lipid overload when hepatic PPAR...

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Bibliographic Details
Main Authors: Chad N. Brocker, Daxesh P. Patel, Thomas J. Velenosi, Donghwan Kim, Tingting Yan, Jiang Yue, Guolin Li, Kristopher W. Krausz, Frank J. Gonzalez
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Journal of Lipid Research
Subjects:
nuclear receptors
lipase
caloric restriction
peroxisome proliferator-activated receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309147

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http://www.sciencedirect.com/science/article/pii/S0022227520309147

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