Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.
DNA methylation patterns are reprogrammed in primordial germ cells and in preimplantation embryos by demethylation and subsequent de novo methylation. It has been suggested that epigenetic reprogramming may be necessary for the embryonic genome to return to a pluripotent state. We have carried out a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-06-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2432031?pdf=render |