Tailored Cyclodextrin Pore Blocker Protects Mammalian Cells from Clostridium difficile Binary Toxin CDT

Tailored Cyclodextrin Pore Blocker Protects Mammalian Cells from Clostridium difficile Binary Toxin CDT

Some Clostridium difficile strains produce, in addition to toxins A and B, the binary toxin Clostridium difficile transferase (CDT), which ADP-ribosylates actin and may contribute to the hypervirulence of these strains. The separate binding and translocation component CDTb mediates transport of the...

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Bibliographic Details
Main Authors: Maurice Roeder, Ekaterina M. Nestorovich, Vladimir A. Karginov, Carsten Schwan, Klaus Aktories, Holger Barth
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Toxins
Subjects:
cellular uptake
Clostridium difficile CDT
binary toxin
membrane transport
translocation pore
pore blocker
β-cyclodextrin
Online Access:http://www.mdpi.com/2072-6651/6/7/2097

Internet

http://www.mdpi.com/2072-6651/6/7/2097

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