Initial In Vivo Evaluation of a Novel Amikacin-Deoxycholate Hydrophobic Salt Delivers New Insights on Amikacin Partition in Blood and Tissues

Initial In Vivo Evaluation of a Novel Amikacin-Deoxycholate Hydrophobic Salt Delivers New Insights on Amikacin Partition in Blood and Tissues

In this study, an initial in vivo evaluation of a new amikacin-deoxycholate hydrophobic salt aimed at potentiating amikacin action against hard-to-treat lung infections was undertaken by quantifying, for the first time, amikacin in whole blood. Pharmacokinetic evaluation after intranasal administrat...

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Bibliographic Details
Main Authors: Styliani Xiroudaki, Federica Ianni, Samuele Sabbatini, Elena Roselletti, Claudia Monari, Roccaldo Sardella, Anna Vecchiarelli, Stefano Giovagnoli
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
amikacin
amikacin-deoxycholate hydrophobic salt
pulmonary delivery
pharmacokinetics
inflammation
amikacin partition
Online Access:https://www.mdpi.com/1999-4923/13/1/85

Internet

https://www.mdpi.com/1999-4923/13/1/85

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