Chimeric Antigen Receptor Signaling Domains Differentially Regulate Proliferation and Native T Cell Receptor Function in Virus-Specific T Cells

Chimeric Antigen Receptor Signaling Domains Differentially Regulate Proliferation and Native T Cell Receptor Function in Virus-Specific T Cells

The efficacy of T cells expressing chimeric antigen receptors (CARs) for solid tumors has been limited by insufficient CAR T cell expansion and persistence. The use of virus-specific T cells (VSTs) as carriers for CARs may overcome this limitation since CAR-VSTs can be boosted by viral vaccines or o...

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Bibliographic Details
Main Authors: Bilal Omer, Paul A. Castillo, Haruko Tashiro, Thomas Shum, Mai T. A. Huynh, Mara Cardenas, Miyuki Tanaka, Andrew Lewis, Tim Sauer, Robin Parihar, Natalia Lapteva, Michael Schmueck-Henneresse, Malini Mukherjee, Stephen Gottschalk, Cliona M. Rooney
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Medicine
Subjects:
adoptive cell therapy
chimeric antigen receptor
virus specific t cells
t cell receptor
signaling domains
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2018.00343/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2018.00343/full

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