Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator

Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator

Saccharomyces cerevisiae cells are killed by zymocin, a tRNase ribotoxin complex from Kluyveromyces lactis, which cleaves anticodons and inhibits protein synthesis. Zymocin’s action requires specific chemical modification of uridine bases in the anticodon wobble position (U34) by the Elongator compl...

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Bibliographic Details
Main Authors: Constance Mehlgarten, Heike Prochaska, Alexander Hammermeister, Wael Abdel-Fattah, Melanie Wagner, Rościsław Krutyhołowa, Sang Eun Jun, Gyung-Tae Kim, Sebastian Glatt, Karin D. Breunig, Michael J. R. Stark, Raffael Schaffrath
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Toxins
Subjects:
zymocin
ribotoxin
tRNase
Kti12
Elongator complex
tRNA anticodon modification
Online Access:https://www.mdpi.com/2072-6651/9/9/272

Internet

https://www.mdpi.com/2072-6651/9/9/272

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