A Computational Investigation of In Vivo Cytosolic Protein Delivery for Cancer Therapy

A Computational Investigation of In Vivo Cytosolic Protein Delivery for Cancer Therapy

The ability to specifically block or degrade cytosolic targets using therapeutic proteins would bring tremendous therapeutic opportunities in cancer therapy. Over the last few years, significant progress has been made with respect to tissue targeting, cytosolic delivery, and catalytic inactivation o...

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Bibliographic Details
Main Authors: Camilo Torres, Simon Dumas, Valentina Palacio-Castañeda, Stéphanie Descroix, Roland Brock, Wouter P. R. Verdurmen
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
binding-site barrier
drug delivery modelling
cytosolic protein delivery
peptide delivery
targeted protein degradation
cancer therapy
Online Access:https://www.mdpi.com/1999-4923/13/4/562

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https://www.mdpi.com/1999-4923/13/4/562

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