Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain.

Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain.

Adeno-associated virus (AAV) mediated gene expression is a powerful tool for gene therapy and preclinical studies. A comprehensive analysis of CNS cell type tropism, expression levels and biodistribution of different capsid serotypes has not yet been undertaken in neonatal rodents. Our previous stud...

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Bibliographic Details
Main Authors: Paramita Chakrabarty, Awilda Rosario, Pedro Cruz, Zoe Siemienski, Carolina Ceballos-Diaz, Keith Crosby, Karen Jansen, David R Borchelt, Ji-Yoen Kim, Joanna L Jankowsky, Todd E Golde, Yona Levites
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3692458?pdf=render

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http://europepmc.org/articles/PMC3692458?pdf=render

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