L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis.

L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis.

Acute renal failure is a common complication caused by Bothrops viper envenomation. In this study, the nefrotoxicity of a main component of B. leucurus venom called L-aminoacid oxidase (LAAO-Bl) was evaluated by using tubular epithelial cell lines MDCK and HK-2 and perfused kidney from rats. LAAO-Bl...

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Bibliographic Details
Main Authors: Isabel C O Morais, Gustavo J S Pereira, M Orzáez, Roberta J B Jorge, Claudia Bincoletto, Marcos H Toyama, Helena S A Monteiro, Soraya S Smaili, Enrique Pérez-Payá, Alice M C Martins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4508040?pdf=render

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http://europepmc.org/articles/PMC4508040?pdf=render

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