Colonic epithelial cathelicidin (LL‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8+ T cell infiltrate

Colonic epithelial cathelicidin (LL‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8+ T cell infiltrate

Abstract Colorectal cancer (CRC) remains a leading cause of cancer mortality. Here, we define the colonic epithelial expression of cathelicidin (LL‐37) in CRC. Cathelicidin exerts pleotropic effects including anti‐microbial and immunoregulatory functions. Genetic knockout of cathelicidin led to incr...

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Bibliographic Details
Main Authors: Ross J Porter, Graeme I Murray, Abdo Alnabulsi, Matthew P Humphries, Jacqueline A James, Manuel Salto‐Tellez, Stephanie G Craig, Ji M Wang, Teizo Yoshimura, Mairi H McLean
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:The Journal of Pathology: Clinical Research
Subjects:
colorectal cancer
LL‐37
cathelicidin
organoid
lymphocytes
Online Access:https://doi.org/10.1002/cjp2.222

Internet

https://doi.org/10.1002/cjp2.222

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