Quantitative analysis of cryptic splicing associated with TDP-43 depletion

Quantitative analysis of cryptic splicing associated with TDP-43 depletion

Abstract Background Reliable exon recognition is key to the splicing of pre-mRNAs into mature mRNAs. TDP-43 is an RNA-binding protein whose nuclear loss and cytoplasmic aggregation are a hallmark pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). TDP-43 depletion cause...

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Bibliographic Details
Main Authors: Jack Humphrey, Warren Emmett, Pietro Fratta, Adrian M. Isaacs, Vincent Plagnol
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Medical Genomics
Subjects:
RNA-seq
Cryptic exons
Splicing
TDP-43
Online Access:http://link.springer.com/article/10.1186/s12920-017-0274-1

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http://link.springer.com/article/10.1186/s12920-017-0274-1

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