Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics.

Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics.

Macrophages are versatile immune cells that can detect a variety of pathogen-associated molecular patterns through their Toll-like receptors (TLRs). In response to microbial challenge, the TLR-stimulated macrophage undergoes an activation program controlled by a dynamically inducible transcriptional...

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Bibliographic Details
Main Authors: Stephen A Ramsey, Sandy L Klemm, Daniel E Zak, Kathleen A Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S Gold, Carrie D Johnson, Vladimir Litvak, Garnet Navarro, Jared C Roach, Carrie M Rosenberger, Alistair G Rust, Natalya Yudkovsky, Alan Aderem, Ilya Shmulevich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2265556?pdf=render

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