Heterologous Combination of VSV-GP and NYVAC Vectors Expressing HIV-1 Trimeric gp145 Env as Vaccination Strategy to Induce Balanced B and T Cell Immune Responses

Heterologous Combination of VSV-GP and NYVAC Vectors Expressing HIV-1 Trimeric gp145 Env as Vaccination Strategy to Induce Balanced B and T Cell Immune Responses

The generation of a vaccine against HIV-1 able to induce durable protective immunity continues a major challenge. The modest efficacy (31.2%) of the phase III RV144 clinical trial provided the first demonstration that a prophylactic HIV/AIDS vaccine is achievable but emphasized the need for further...

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Bibliographic Details
Main Authors: Beatriz Perdiguero, Carmen Elena Gómez, Juan García-Arriaza, Cristina Sánchez-Corzo, Carlos Óscar S. Sorzano, Sarah Wilmschen, Dorothee von Laer, Benedikt Asbach, Christina Schmalzl, David Peterhoff, Song Ding, Ralf Wagner, Janine Kimpel, Yves Levy, Giuseppe Pantaleo, Mariano Esteban
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
HIV-1 Env
vaccine
VSV-GP
NYVAC
mice immunization
T and B cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02941/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02941/full

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