YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by <i>Rbpj</i> Deletion

YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by <i>Rbpj</i> Deletion

Liver cholestasis is a chronic liver disease and a major health problem worldwide. Cholestasis is characterised by a decrease in bile flow due to impaired secretion by hepatocytes or by obstruction of bile flow through intra- or extrahepatic bile ducts. Thereby cholestasis can induce ductal prolifer...

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Bibliographic Details
Main Authors: Umesh Tharehalli, Michael Svinarenko, Johann M. Kraus, Silke D. Kühlwein, Robin Szekely, Ute Kiesle, Annika Scheffold, Thomas F.E. Barth, Alexander Kleger, Reinhold Schirmbeck, Hans A. Kestler, Thomas Seufferlein, Franz Oswald, Sarah-Fee Katz, André Lechel
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
Notch signalling pathway
cholestasis
YAP activation
Hippo signalling pathway
hepatocyte transdifferentiation
maturation of bile ducts
Online Access:https://www.mdpi.com/1422-0067/19/12/3801

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https://www.mdpi.com/1422-0067/19/12/3801

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