Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

The Gram-negative bacterial cell wall component lipopolysaccharide (LPS) is recognized by the noncanonical inflammasome protein caspase-11 in the cytosol of infected host cells and thereby prompts an inflammatory immune response linked to sepsis. Host guanylate binding proteins (GBPs) promote infect...

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Bibliographic Details
Main Authors: Ryan Finethy, Sarah Luoma, Nichole Orench-Rivera, Eric M. Feeley, Arun K. Haldar, Masahiro Yamamoto, Thirumala-Devi Kanneganti, Meta J. Kuehn, Jorn Coers, David S. Weiss, Eric J. Rubin
Format: Article
Language:English
Published: American Society for Microbiology 2017-10-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/5/e01188-17

Internet

http://mbio.asm.org/cgi/content/full/8/5/e01188-17

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