Therapeutic approaches for tumor necrosis factor inhibition

Therapeutic approaches for tumor necrosis factor inhibition

Tumor necrosis factor (TNF) consists of an inflammatory cytokine essential for homeostasis and organism defense. Despite its physiological relevance, both increased biosynthesis and release of TNF lead to the exacerbation of inflammatory and oxidative responses, which are related to the pathogenesis...

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Bibliographic Details
Main Authors: Maria Letícia de Castro Barbosa, Milla Machado Fumian, Ana Luísa Palhares de Miranda, Eliezer J. Barreiro, Lídia Moreira Lima
Format: Article
Language:English
Published: Universidade de São Paulo 2011-09-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Fator de necrose tumoral
TACE
MAPK p38
NF-κB
AMPc
Fosfodiesterase
Receptor de adenosina
Tumor necrosis factor
p38 MAPK
cAMP
Phosphodiesterase
Adenosine receptor
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300002

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300002

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