Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes.

Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes.

Late endosome-resident interferon-induced transmembrane protein 3 (IFITM3) inhibits fusion of diverse viruses, including Influenza A virus (IAV), by a poorly understood mechanism. Despite the broad antiviral activity of IFITM3, viruses like Lassa virus (LASV), are fully resistant to its inhibitory e...

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Bibliographic Details
Main Authors: Krishna C Suddala, Christine C Lee, Paul Meraner, Mariana Marin, Ruben M Markosyan, Tanay M Desai, Fredric S Cohen, Abraham L Brass, Gregory B Melikyan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007532

Internet

https://doi.org/10.1371/journal.ppat.1007532

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