Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown.

Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown.

In utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much train...

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Bibliographic Details
Main Authors: Tracy M Centanni, Fuyi Chen, Anne M Booker, Crystal T Engineer, Andrew M Sloan, Robert L Rennaker, Joseph J LoTurco, Michael P Kilgard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4037188?pdf=render

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http://europepmc.org/articles/PMC4037188?pdf=render

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