Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD)

Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD)

FacioScapuloHumeral muscular Dystrophy (FSHD) is one of the most prevalent hereditary myopathies and is generally characterized by progressive muscle atrophy affecting the face, scapular fixators; upper arms and distal lower legs. The FSHD locus maps to a macrosatellite D4Z4 repeat array on chromoso...

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Bibliographic Details
Main Authors: Eugénie Ansseau, Céline Vanderplanck, Armelle Wauters, Scott Q. Harper, Frédérique Coppée, Alexandra Belayew
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Genes
Subjects:
double homeobox
splicing interference
polyadenylation
primary myoblasts
myopathy
Online Access:http://www.mdpi.com/2073-4425/8/3/93

Internet

http://www.mdpi.com/2073-4425/8/3/93

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