Adenovirus-Mediated Glial Cell Line-Derived Neurotrophic Factor (GDNF) Expression Protects against Subsequent Cortical Cold Injury in Rats

Adenovirus-Mediated Glial Cell Line-Derived Neurotrophic Factor (GDNF) Expression Protects against Subsequent Cortical Cold Injury in Rats

We examined whether brain damage after focal cortex trauma may be attenuated by adenoviral delivery of the glial cell line-derived neurotrophic factor (GDNF) gene. For this reason, injections of vehicle, of an adenoviral vector deleted in the E1 region (Ad-dE1) or a vector expressing the GDNF gene f...

Full description

Bibliographic Details
Main Authors: Dirk M. Hermann, Ertugrul Kilic, Sebastian Kügler, Stefan Isenmann, Mathias Bähr
Format: Article
Language:English
Published: Elsevier 2001-12-01
Series:Neurobiology of Disease
Subjects:
adenoviral gene therapy
brain trauma
cortex trauma
neurotrophin
nitric oxide synthetase
vasogenic edema
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904486

Internet

http://www.sciencedirect.com/science/article/pii/S0969996101904486

Similar Items