Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients

Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients

Abstract Background Enterococcus faecium is a leading cause of hospital-acquired infection, particularly in the immunocompromised. Here, we use whole genome sequencing of E. faecium to study within-host evolution and the transition from gut carriage to invasive disease. Methods We isolated and seque...

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Bibliographic Details
Main Authors: Danesh Moradigaravand, Theodore Gouliouris, Beth Blane, Plamena Naydenova, Catherine Ludden, Charles Crawley, Nicholas M. Brown, M. Estée Török, Julian Parkhill, Sharon J. Peacock
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Genome Medicine
Subjects:
Enterococcus faecium
Within-host evolution
Genome sequencing
Online Access:http://link.springer.com/article/10.1186/s13073-017-0507-0

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http://link.springer.com/article/10.1186/s13073-017-0507-0

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