The discriminatory power of the T cell receptor

The discriminatory power of the T cell receptor

T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) antigens. Although the discriminatory power of the TCR is widely believed to be near-perfect, technical difficulties have h...

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Bibliographic Details
Main Authors: Johannes Pettmann, Anna Huhn, Enas Abu Shah, Mikhail A Kutuzov, Daniel B Wilson, Michael L Dustin, Simon J Davis, P Anton van der Merwe, Omer Dushek
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
T cells
T cell receptor
co-signalling receptors
antigen discrimination
kinetic proofreading
mathematical model
Online Access:https://elifesciences.org/articles/67092

Internet

https://elifesciences.org/articles/67092

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