Bronchial smooth muscle cells of asthmatics promote angiogenesis through elevated secretion of CXC-chemokines (ENA-78, GRO-α, and IL-8).

<h4>Background</h4>Airway wall remodelling is a key pathology of asthma. It includes thickening of the airway wall, hypertrophy and hyperplasia of bronchial smooth muscle cells (BSMC), as well as an increased vascularity of the sub-epithelial cell layer. BSMC are known to be the effector...

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Main Authors: Laura Keglowich, Michael Roth, Maria Philippova, Thérèse Resink, Gavin Tjin, Brian Oliver, Didier Lardinois, Sophie Dessus-Babus, Reinoud Gosens, Katrin Hostettler Haack, Michael Tamm, Peter Borger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24339939/pdf/?tool=EBI