Marine Derived Hamacanthins as Lead for the Development of Novel PDGFRβ Protein Kinase Inhibitors

Marine Derived Hamacanthins as Lead for the Development of Novel PDGFRβ Protein Kinase Inhibitors

In this study, we report on pyrazin-2(1H)-ones as lead for the development of potent adenosine triphosphate (ATP) competitive protein kinase inhibitors with implications as anti-cancer drugs. Initially, we identified the pyrazin-2(1H)-one scaffold from hamacanthins (deep sea marine sponge alkaloids)...

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Bibliographic Details
Main Authors: Christian Peifer, Frank Totzke, Christoph Schaechtele, Sheraz Gul, Joachim Schlosser, Eugen Johannes, Boris Pinchuk
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Marine Drugs
Subjects:
marine sponge derived hamacanthins
pyrazin-2(1H)-ones
receptor tyrosine kinases
PDGFR inhibitors
anti-cancer activity
Online Access:http://www.mdpi.com/1660-3397/11/9/3209

Internet

http://www.mdpi.com/1660-3397/11/9/3209

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