Single-Cell Analysis of Multiple Steps of Dynamic NF-κB Regulation in Interleukin-1α-Triggered Tumor Cells Using Proximity Ligation Assays

Single-Cell Analysis of Multiple Steps of Dynamic NF-κB Regulation in Interleukin-1α-Triggered Tumor Cells Using Proximity Ligation Assays

The frequently occurring heterogeneity of cancer cells and their functional interaction with immune cells in the tumor microenvironment raises the need to study signaling pathways at the single cell level with high precision, sensitivity, and spatial resolution. As aberrant NF-κB activity h...

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Bibliographic Details
Main Authors: Christin Mayr-Buro, Eva Schlereth, Knut Beuerlein, Ulas Tenekeci, Johanna Meier-Soelch, M. Lienhard Schmitz, Michael Kracht
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
tumor heterogeneity
NF-κB
interleukin-1 signaling
transcription
posttranscriptional gene regulation
P-bodies
DCP1a
proximity ligation assays
single cell analysis
Online Access:https://www.mdpi.com/2072-6694/11/8/1199

Internet

https://www.mdpi.com/2072-6694/11/8/1199

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