Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone

Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone

ABSTRACT Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation. Bone morphogenetic protein 4 (BMP4) is important for both pre‐ and postnatal...

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Bibliographic Details
Main Authors: Marita Westhrin, Toril Holien, Muhammad Zahoor, Siv Helen Moen, Glenn Buene, Berit Størdal, Hanne Hella, Huipin Yuan, Joost D deBruijn, Anton Martens, Richard WJ Groen, Fatima Bosch, Ulf Smith, Anne‐Marit Sponaas, Anders Sundan, Therese Standal
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:JBMR Plus
Subjects:
BMPs/TGF‐βs
Cancer
Osteoblast
Osteoclasts
Tumor‐induced bone disease
Online Access:https://doi.org/10.1002/jbm4.10247

Internet

https://doi.org/10.1002/jbm4.10247

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