Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Abstract Abnormal accumulation of alpha-synuclein (αsyn) is a pathological hallmark of Lewy body related disorders such as Parkinson’s disease and Dementia with Lewy body disease. During the past two decades, a myriad of animal models have been developed to mimic pathological features of synucleinop...

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Bibliographic Details
Main Authors: Marion Delenclos, Ayman H. Faroqi, Mei Yue, Aishe Kurti, Monica Castanedes-Casey, Linda Rousseau, Virginia Phillips, Dennis W. Dickson, John D. Fryer, Pamela J. McLean
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Acta Neuropathologica Communications
Subjects:
Alpha-synuclein
Neonatal injection
Viral vector model
Aggregation
Online Access:http://link.springer.com/article/10.1186/s40478-017-0455-3

Internet

http://link.springer.com/article/10.1186/s40478-017-0455-3

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